Iron-Catalyzed Amidation of Alkynyl Bromides: A Facile Route for the Preparation of Ynamides
Bangben Yao, Zunjun Liang, Tianmin Niu and Yuhong Zhang*
*Department of Chemistry, Zhejiang University, Hangzhou
310027, People's Republic of China, Email: yhzhangzju.edu.cn
B. Yao, Z. Liang, T. Niu, Y. Zhang, J. Org. Chem., 2009, 74, 4630-4633.
DOI: 10.1021/jo900595c
Abstract
A facile route to ynamides in high yields was achieved through an iron-catalyzed C-N coupling reaction of amides with alkynyl bromides in the presence of 20 mol % of N,N′-dimethylethane-1,2-diamine (DMEDA).
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Key Words
sulfonamides, amides, carbamates, alkynyl bromides
ID: J42-Y2009-1830