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A Simple, General, and Highly Chemoselective Acetylation of Alcohols Using Ethyl Acetate as the Acetyl Donor Catalyzed by a Tetranuclear Zinc Cluster

Takanori Iwasaki, Yusuke Maegawa, Yukiko Hayashi, Takashi Ohshima*, Kazushi Mashima*

*Department of Chemistry, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan, USA, Email:,

T. Iwasaki, Y. Maegawa, Y. Hayashi, T. Ohshima, K. Mashima, Synlett, 2009, 1659-1663.

DOI: 10.1055/s-0029-1217335


In the presence of a Zn-cluster catalyst, alcohols are efficiently converted to the corresponding acetates in very good yields just by refluxing in EtOAc. The mild reaction conditions enabled a selective acetylation of various functionalized alcohols even in the presence of highly nucleophilic aliphatic amino groups.

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Transesterification of Various Methyl Esters Under Mild Conditions Catalyzed by Tetranuclear Zinc Cluster

T. Iwasaki, Y. Maegawa, Y. Hayashi, T. Ohshima, K. Mashima, J. Org. Chem., 2008, 73, 5147-5150.

Key Words

zinc clusters, catalysis, acetylations, transesterifications, green chemistry

ID: J60-Y2009-1870