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A Novel Synthesis of Aryl Mesylates via One-Pot Demethylation-Mesylation of Aryl Methyl Ethers Using a Mixture of Phosphorus Pentoxide in Methanesulfonic Acid

Babak Kaboudin*, Yaghoub Abedi

*Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS) Gava Zang, Zanjan 45195-1159, Iran, Email:

B. Kaboudin, Y. Abedi, Synthesis, 2009, 2025-2028.

DOI: 10.1055/s-0029-1216790


Treatment of a various aryl methyl ethers with a mixture of phosphorus pentoxide in methanesulfonic acid enables a simple and efficient one-pot demethylation-mesylation reaction to afford the corresponding aryl mesylates in good yields.

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Key Words

Eaton's reagent, demethylation, mesylation, one-pot reaction, aryl mesylates

ID: J66-Y2009-1880