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Synthesis of 5,5-Disubstituted Butenolides Based on a Pd-Catalyzed γ-Arylation Strategy

Alan M. Hyde and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

A. M. Hyde, S. L. Buchwald, Org. Lett., 2009, 11, 2663-2666.

DOI: 10.1021/ol9007102

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A Pd-catalyzed arylation of butenolides with high selectivity for the γ-position allows a facile construction of quaternary centers. The preparation of a wide variety of γ-aryl butenolides containing a number of functional groups is outlined.

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ID: J54-Y2009-1890