Synthesis of 5,5-Disubstituted Butenolides Based on a Pd-Catalyzed γ-Arylation Strategy
Alan M. Hyde and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: sbuchwalmit.edu
A. M. Hyde, S. L. Buchwald, Org. Lett., 2009, 11, 2663-2666.
DOI: 10.1021/ol9007102 (free Supporting Information)
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A Pd-catalyzed arylation of butenolides with high selectivity for the γ-position allows a facile construction of quaternary centers. The preparation of a wide variety of γ-aryl butenolides containing a number of functional groups is outlined.
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