Organic Chemistry Portal

Abstracts

Search:

Microwave-Assisted Ester Formation Using O-Alkylisoureas: A Convenient Method for the Synthesis of Esters with Inversion of Configuration

Alessandra Chighine, Stefano Crosignani, Marie-Claire Arnal, Mark Bradley and Bruno Linclau*

*School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom, Email: bruno.linclausoton.ac.uk

A. Chighine, S. Crosignani, M.-C. Arnal, M. Bradley, B. Linclau, J. Org. Chem., 2009, 74, 4638-4641.

DOI: 10.1021/jo900476y (free Supporting Information)


Abstract

A very fast, microwave-assisted formation of carboxylic esters via reaction of carboxylic acids with O-alkylisoureas derived from primary and secondary alcohols proceeds in good yields with clean inversion of configuration where appropriate. The reaction works well with very hindered carboxylic acids.


see article for more examples



Key Words

Esters, Microwave Synthesis


ID: J42-Y2009-1940