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Practical Synthesis of 5-Substituted Tetrazoles under Microwave Irradiation

Jaroslav Roh*, Tatjana V. Artamonova, Kateřina Vávrová, Grigorii I. Koldobskii, Alexandr Hrabálek

*Faculty of Pharmacy, Centre for New Antivirals and Antineoplastics, Charles University, Heyrovského 1203, 50005 Hradec Kralove, Czech Republic, Email:

J. Roh, T. V. Artamonova, K. Vávrová, G. I. Koldobskii, A. Hrabálek, Synthesis, 2009, 2175-2178.

DOI: 10.1055/s-0029-1216840


5-Substituted tetrazoles were prepared in very good yields and short reaction times by treatment of nitriles with sodium azide and triethylammonium chloride in nitrobenzene in a microwave reactor. Even sterically hindered tetrazoles, as well as those deactivated by electron-donating groups, can be prepared.

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Key Words

tetrazoles, microwave synthesis, sodium azide, heterocycles, nitriles

ID: J66-Y2009-1970