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Synthesis of 4,5-Substituted Imidazoles by a Fast Condensation of 1,2-Diketones and Urotropine in Heterogeneous Medium

George Bratulescu*

*University of Craiova, Faculty of Chemistry, 13 A.I. Cuza, 200396 Craiova, Romania, Email:

G. Bratulescu, Synthesis, 2009, 2319-2320.

DOI: 10.1055/s-0029-1216841


Starting from 1,2-diketones and urotropine in the presence of ammonium acetate, a simple and efficient solventless microwave-assisted enabled the synthesis of 4,5-disubstituted imidazoles.

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Key Words

heterocycles, 4,5-disubstituted imidazoles, ketones, urotropine, microwave synthesis

ID: J66-Y2009-2030