A Safe, Convenient and Efficient One-Pot Synthesis of α-Chloroketone Acetals Directly from Ketones Using Iodobenzene Dichloride
Jun Yu, Chi Zhang*
*The State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. of China, Email: zhangchinankai.edu.cn
J. Yu, C. Zhang, Synthesis, 2009, 2324-2328.
Aliphatic and aromatic ketones can be directly converted into their corresponding α-chloroketone acetals in very good yields using iodobenzene dichloride in ethylene glycol in the presence of 4 Å molecular sieves at room temperature.
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ketones, iodobenzene dichloride, α-chlorination, hypervalent iodine, cyclic acetals