A Safe, Convenient and Efficient One-Pot Synthesis of α-Chloroketone Acetals Directly from Ketones Using Iodobenzene Dichloride
Jun Yu, Chi Zhang*
*The State Key Laboratory of Elemento-Organic Chemistry,
Nankai University, Tianjin 300071, P. R. of China, Email: zhangchi
nankai.edu.cn
J. Yu, C. Zhang, Synthesis, 2009, 2324-2328.
DOI: 10.1055/s-0029-1216856
Abstract
Aliphatic and aromatic ketones can be directly converted into their corresponding α-chloroketone acetals in very good yields using iodobenzene dichloride in ethylene glycol in the presence of 4 Å molecular sieves at room temperature.
see article for more examples
proposed mechanism
Key Words
ketones, iodobenzene dichloride, α-chlorination, hypervalent iodine, cyclic acetals
ID: J66-Y2009-2070
