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Facile One-Pot Synthesis of 4,5-Disubstituted 1,2,3-(NH)-Triazoles through Sonogashira Coupling/1,3-Dipolar Cycloaddition of Acid Chlorides, Terminal Acetylenes, and Sodium Azide

Jihui Li, Dong Wang, Yuanqing Zhang, Jiting Li and Baohua Chen*

*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Gansu Lanzhou 730000, P. R. China, Email:

J. Li, D. Wang, Y. Zhang, J. Li, B. Chen, Org. Lett., 2009, 11, 3024-3027.

DOI: 10.1021/ol901040d (free Supporting Information)


A palladium-catalyzed and ultrasonic promoted Sonogashira coupling/1,3-dipolar cycloaddition of acid chlorides, terminal acetylenes, and sodium azide in one pot enables an efficient synthesis of 4,5-disubstituted-1,2,3-(NH)-triazoles in excellent yields.

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Key Words

2H-1,2,3-Triazoles, Sonochemistry

ID: J54-Y2009-2100