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Syntheses of Substituted Furans and Pyrroles by Platinum-Catalyzed Cyclizations of Propargylic Oxiranes and Aziridines in Aqueous Media

Masahiro Yoshida*, Mohammad Al-Amin, Kozo Shishido

*Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima 770-8505, Japan, Email:

M. Yoshida, M. Al-Amin, K. Shishido, Synthesis, 2009, 2454-2466.

DOI: 10.1055/s-0029-1216867

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Highly substituted furans were conveniently synthesized by the platinum-catalyzed reaction of propargylic oxiranes. Propargylic aziridines were also reacted with the platinum catalyst to produce the corresponding substituted pyrroles in good yields.

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Key Words

alkynes, epoxides, furans, platinum, pyrroles

ID: J66-Y2009-2180