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One-Pot Synthesis of Functionalized Benzimidazoles and 1H-Pyrimidines via Cascade Reactions of o-Aminoanilines or Naphthalene-1,8-diamine with Alkynes and p-Tolylsulfonyl Azide

Jin She, Zheng Jiang, Yanguang Wang*

*Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. of China, Email: orgwygzju.edu.cn

J. She, Z. Jiang, Y. Wang, Synlett, 2009, 2023-2027.

DOI: 10.1055/s-0029-1217515


Abstract

Efficient and general cascade reactions of o-aminoanilines or naphthalene-1,8-diamine with terminal alkynes and p-tolylsulfonyl azide allow a one-pot synthesis of functionalized benzimidazoles and 1H-pyrimidines in good yields.


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Key Words

benzimidazoles, 1H-pyrimidines, o-aminoanilines, naphthalene-1,8-diamine, alkynes


ID: J60-Y2009-2190