Access to Flavones via a Microwave-Assisted, One-Pot Sonogashira-Carbonylation-Annulation Reaction

Emelia Awuah and Alfredo Capretta*

*Department of Chemistry, McMaster University, Hamilton, Ontario, Canada L8S 4M1, Email: caprettamcmaster.ca

E. Awuah, A. Capretta, Org. Lett., 2009, 11, 3210-3213.

DOI: 10.1021/ol901043q

Abstract

A palladium complex of 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phosphaadamantane is an effective catalyst for a sequential microwave-assisted Sonogashira and carbonylative annulation reaction to give substituted flavones.

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Key Words

Sonogashira Coupling, Flavones, Microwave Synthesis, Multicomponent Reactions

ID: J54-Y2009-2310