Pd(II)-Catalyzed Amination of C-H Bonds Using Single-Electron or Two-electron Oxidants

Tian-Sheng Mei, Xisheng Wang and Jin-Quan Yu*

*Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, Email: yu200scripps.edu

T.-S. Mei, X. Wang, J.-Q. Yu, J. Am. Chem. Soc., 2009, 131, 10806-10807.

DOI: 10.1021/ja904709b

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Abstract

Pd(II)-catalyzed intramolecular amination of arenes using either Ce(SO₄)₂ as a one- or N-fluoro-2,4,6-trimethylpyridinium triflate as a two-electron oxidant tolerates a wide range of functional groups including acetyl, cyano, and nitro. This catalytic reaction allows expedient syntheses of broadly useful substituted indolines or indoles.

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Key Words

N-fluoro-2,4,6-trimethylpyridinium triflate, indolines

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ID: J48-Y2009-2320