Pd(PPh₃)₄-PEG 400 Catalyzed Protocol for the Atom-Efficient Stille Cross-Coupling Reaction of Organotin with Aryl Bromides

Wen-Jun Zhou, Ke-Hu Wang and Jin-Xian Wang*

*Institute of Chemistry, Department of Chemistry, Northwest Normal University, 967 An Ning Road (E.), Lanzhou 730070, P. R. China, Email: wangjxnwnu.edu.cn

H. Huang, H. Jiang, K. Chen, H. Liu, J. Org. Chem., 2009, 74, 5599-5602.

DOI: 10.1021/jo9005206

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Abstract

Aryl bromides (4 eq.) were coupled efficiently with organotin (1 eq.) using the tetra(triphenylphosphine)palladium/polyethylene glycol 400 catalytic system in the presence of sodium acetate as base at 100°C, providing excellent yields of the corresponding substituted aryls in short reaction times.

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Key Words

Stille Coupling, Arylation, Alkylation

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ID: J42-Y2009-2330