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PTSA-ZnCl2: An Efficient Catalyst for the Synthesis of 1,2,4-Oxadiazoles from Amidoximes and Organic Nitriles

John Kallikat Augustine*, Vani Akabote, Shrivatsa Ganapati Hegde and Padma Alagarsamy

*Syngene International Ltd., Biocon Park, Plot Nos. 2 & 3, Bommasandra IV Phase, Jigani Link Road, Bangalore 560 099, India, Email: john.kallikatsyngeneintl.com

J. K. Augustine, V. Akabote, S. G. Hegde, P. Alagarsamy, J. Org. Chem., 2009, 74, 5640-5643.

DOI: 10.1021/jo900818h (free Supporting Information)


Abstract

PTSA-ZnCl2 is an efficient and mild catalyst for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles from amidoximes and organic nitriles.

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Key Words

1,2,4-Oxadiazoles


ID: J42-Y2009-2370