Iridium-Catalyzed Coupling Reaction of Primary Alcohols with 1-Aryl-1-propynes Leading to Secondary Homoallylic Alcohols
Yasushi Obora*, Shintaro Hatanaka and Yasutaka Ishii
*Department of Chemistry and Materials Engineering, Faculty of Chemistry, Kansai University, Suita, Osaka 564-8680, Japan, Email: oboraipcku.kansai-u.ac.jp
Y. Obora, S. Hatanaka, Y. Ishii, Org. Lett., 2009, 11, 3510-3513.
DOI: 10.1021/ol901366q (free Supporting Information)
An iridium-catalyzed coupling of 1-aryl-1-propynes with primary alcohols gives secondary homoallylic alcohols as products. This reaction involves an iridium-catalyzed novel catalytic transformation of 2-alkynes and primary alcohols through the formation of hydrido(π-allyl)iridium as a possible key intermediate.
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