Iridium-Catalyzed X-H Insertions of Sulfoxonium Ylides
Ian K. Mangion*, Ikenna K. Nwamba, Michael Shevlin and Mark A. Huffman
*Department of Process Research, Merck and Co., Inc., P.O.
Box 2000, Rahway, New Jersey 07065, Email: ian_mangion
merck.com
I. K. Mangion, I. K. Nwamba, M. Shevlin, M. A. Huffman, Org. Lett., 2009, 11, 3566-3569.
DOI: 10.1021/ol901298p
see article for more reactions
Abstract
A simple, commercially available iridium catalyst allows the use of sulfoxonium ylides as a carbene source for various intra- and intermolecular X-H bond insertions, including a practical ring-expansion strategy for lactams. The safety and stability of sulfoxonium ylides recommend them as preferable surrogates to traditional diazo ketones and esters.
see article for more examples
Key Words
ID: J54-Y2009-2460
