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Protic Acid Immobilized on Solid Support as an Extremely Efficient Recyclable Catalyst System for a Direct and Atom Economical Esterification of Carboxylic Acids with Alcohols

Asit K. Chakraborti*, Bavneet Singh, Sunay V. Chankeshwara and Alpesh R. Patel

*Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar 160 062, Punjab, India, Email:

A. K. Chakraborti, B. Singh, S. V. Chankeshwara, A. R. Patel, J. Org. Chem., 2009, 74, 5967-5974.

DOI: 10.1021/jo900614s


A convenient and clean esterification of equimolar amounts of carboxylic acids with alcohols is catalyzed by an easy to prepare catalyst system of perchloric acid immobilized on silica gel (HClO4-SiO2). Esters of long-chain acids and alcohols are obtained in high yields. The catalyst is recovered and recycled without significant loss of activity.

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Key Words

Fischer Esterification, Esterification

ID: J42-Y2009-2480