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Ytterbium Triflate: A Highly Active Catalyst for Addition of Amines to Carbodiimides to N,N',N''-Trisubstituted Guanidines

Xuehua Zhu, Zhu Du, Fan Xu and Qi Shen*

*Key Laboratory of Organic Synthesis of Jiangsu Province, Department of Chemistry and Chemical Engineering, Dushu Lake Campus, Suzhou University, Suzhou 215123, People's Republic of China, Email:

X. Zhu, Z. Du, F. Xu, Q. Shen, J. Org. Chem., 2009, 74, 6347-6349.

DOI: 10.1021/jo900903t


Ytterbium triflate is an efficient catalyst for the addition of a wide scope of amines to carbodiimides under solvent-free condition to provide N,N',N''-trisubstituted guanidines in good yields.

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ID: J42-Y2009-2530