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One-Pot Synthesis of Unsymmetrical N-Heterocyclic Carbene Ligands from N-(2-Iodoethyl)arylamine Salts

B. A. Bhanu Prasad and Scott R. Gilbertson*

*Department of Chemistry, University of Houston, Houston, TX 77204-50030, Email:

B. A. B. Prasad, S. R. Gilbertson, Org. Lett., 2009, 11, 3710-3713.

DOI: 10.1021/ol901189m (free Supporting Information)

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Reaction of iodoethanol with aniline provides N-(2-iodoethyl)arylamine salts that are then converted to the corresponding iodide. A subsequent reaction with aliphatic or aromatic amines followed by triethyl orthoformate gave 26 different NHC ligands.

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Key Words

Imidazolium Salts, Multicomponent Reactions

ID: J54-Y2009-2550