Iron-Catalyzed Inexpensive and Practical Synthesis of N-Substituted Pyrroles in Water
Najmedin Azizi*, Alireza Khajeh-Amiri, Hossein Ghafuri, Mohammad Bolourtchian, Mohammad Reza Saidi
*Chemistry & Chemical Engineering Research Center of Iran, P.O. Box 14335-186, Tehran, Iran, Email: aziziccerci.ac.ir
N. Azizi, A. Khajeh-Amiri, H. Ghafuri, M. Bolourtchian, M. R. Saidi, Synlett, 2009, 2245-2248.
DOI: 10.1055/s-0029-1217799 (free Supporting Information)
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An operationally simple, practical, and economical Paal-Knorr pyrrole condensation of 2,5-dimethoxytetrahydrofuran with various amines and sulfonamines in water in the presence of a catalytic amount of iron(III) chloride allows the synthesis of N-substituted pyrroles under very mild reaction conditions in good to excellent yields.
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