Iron-Catalyzed Inexpensive and Practical Synthesis of N-Substituted Pyrroles in Water
Najmedin Azizi*, Alireza Khajeh-Amiri, Hossein Ghafuri, Mohammad Bolourtchian, Mohammad Reza Saidi
*Chemistry & Chemical Engineering Research Center of Iran,
P.O. Box 14335-186, Tehran, Iran, Email: azizi
ccerci.ac.ir
N. Azizi, A. Khajeh-Amiri, H. Ghafuri, M. Bolourtchian, M. R. Saidi, Synlett, 2009, 2245-2248.
DOI: 10.1055/s-0029-1217799
see article for more reactions
Abstract
An operationally simple, practical, and economical Paal-Knorr pyrrole condensation of 2,5-dimethoxytetrahydrofuran with various amines and sulfonamines in water in the presence of a catalytic amount of iron(III) chloride allows the synthesis of N-substituted pyrroles under very mild reaction conditions in good to excellent yields.
see article for more examples
Key Words
pyrroles, Paal-Knorr pyrrole synthesis, amines, iron, water chemistry, green chemistry, dimethoxytetrahydrofuran
ID: J60-Y2009-2580
