Rhodium-Catalyzed Highly Enantioselective Direct Intermolecular Hydroacylation of 1,1-Disubstituted Alkenes with Unfunctionalized Aldehydes
Yu Shibata and Ken Tanaka*
*Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan, Email: tanaka-kcc.tuat.ac.jp
Y. Shibata, K. Tanaka, J. Am. Chem. Soc., 2009, 131, 12552-12553.
DOI: 10.1021/ja905908z (free Supporting Information)
A cationic rhodium(I)/(R,R)-QuinoxP* complex catalyzes a highly enantioselective direct intermolecular hydroacylation of α-substituted acrylamides with unfunctionalized aliphatic aldehydes to yield the corresponding γ-ketoamides in high yields with excellent ee values.
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K. Tanaka, Y. Shibata, T. Suda, Y. Hagiwara, M. Hirano, Org. Lett., 2007, 9, 1215-1218.