Efficient and Regioselective One-Pot Synthesis of 3-Substituted and 3,5-Disubstituted Isoxazoles
Shibing Tang, Jinmei He, Yongquan Sun, Liuer He and Xuegong She*
*State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. China, Email: shexglzu.edu.cn
S. Tang, J. He, Y. Sun, L. He, X. She, Org. Lett., 2009, 11, 3982-3985.
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Various 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in good yields by the reaction of N-hydroxyl-4-toluenesulfonamide with α,β-unsaturated carbonyl compounds. This strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.
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