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Pd-Catalyzed Conversion of Aryl Chlorides, Triflates, and Nonaflates to Nitroaromatics

Brett P. Fors and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

B. P. Fors, S. L. Buchwald, J. Am. Chem. Soc., 2009, 131, 12898-12899.

DOI: 10.1021/ja905768k


An efficient Pd-catalyzed transformation of aryl chlorides, triflates, and nonaflates to nitroaromatics proceeds under weakly basic conditions and displays a broad scope and excellent functional group compatibility. Moreover, this method allows the synthesis of aromatic nitro compounds that cannot be accessed efficiently via other nitration protocols.

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Key Words

nitro compounds

ID: J48-Y2009-2670