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General Procedure for the Palladium-Catalyzed Selective Hydrophosphorylation of Alkynes

Valentine P. Ananikov*, Levon L. Khemchyan, Irina P. Beletskaya*

*Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow 119991, Russian Federation, Email:

V. P. Ananikov, L. L. Khemchyan, I. P. Beletskaya, Synlett, 2009, 2375-2381.

DOI: 10.1055/s-0029-1217739 (free Supporting Information)


A low-ligated palladium/triphenylphosphane catalytic system in the presence of a catalytic amount of trifluoroacetic acid allows a hydrophosphorylation of terminal and internal alkynes with high isolated yields and excellent regio- and stereoselectivity. The catalytic system permits the formation of diverse alkenylphosphonates utilizing various available H-phosphonates and alkynes.

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Key Words

addition reactions, alkynes, palladium, homogenous catalysis, phosphorylations

ID: J60-Y2009-2720