Thio FCMA Intermediates as Strong Acyl Donors: A General Solution to the Formation of Complex Amide Bonds
Yu Rao, Xuechen Li and Samuel J. Danishefsky*
*Laboratory for Bioorganic Chemistry, Sloan-Kettering
Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, Email:
s-danishefsky
ski.mskcc.org
Y. Rao, X. Li, S. J. Danishefsky, J. Am. Chem. Soc., 2009, 131, 12924-12926.
DOI: 10.1021/ja906005j
Abstract
Thio FCMA intermediates, generated from the reactions of thioacids with isonitriles, are active acyl donors, that form amide bonds under neutral conditions.
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proposed reaction pathway
Key Words
ID: J48-Y2009-2740
