Transfer Hydrogenation in Water: Enantioselective, Catalytic Reduction of (E)-β,β-Disubstituted Nitroalkenes
Omid Soltani, Martin A. Ariger and Erick M. Carreira*
*Laboratorium für Organische Chemie, ETH Zürich, HCI H335,
CH-8093 Zürich, Switzerland, Email: carreiraorg.chem.ethz.ch
O. Soltani, M. A. Ariger, E. M. Carreira, Org. Lett., 2009, 11, 4196-4198.
DOI: 10.1021/ol901332e
Abstract
A mild catalytic asymmetric transfer hydrogenation of β,β-disubstituted nitroalkenes using formic acid as reductant in combination with an Ir catalyst is conducted in water at low pH and open to air to give products in good yield and selectivity.
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O. Soltani, M. A. Ariger, H. Vázquez-Villa, E. M. Carreira, Org. Lett., 2010, 12, 2893-2895.
Key Words
reduction of alkenes, formic acid, green chemistry
ID: J54-Y2009-2760