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Air-Stable Secondary Phosphine Oxide as Preligand for Palladium-Catalyzed Intramolecular α-Arylations with Chloroarenes

Lutz Ackermann*, Rubén Vicente and Nora Hofmann

*Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077 Göttingen, Germany, Email: lutz.ackermannchemie.uni-goettingen.de

L. Ackermann, R. Vicente, N. Hofmann, Org. Lett., 2009, 11, 4274-4276.

DOI: 10.1021/ol901597d (free Supporting Information)


Abstract

A palladium catalyst derived from an air-stable secondary phosphine oxide enabled efficient intramolecular α-arylations of amides with aryl chlorides to give various substituted oxindoles and azaoxindoles in good yield.

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Key Words

Oxindoles


ID: J54-Y2009-2820