Air-Stable Secondary Phosphine Oxide as Preligand for Palladium-Catalyzed Intramolecular α-Arylations with Chloroarenes
Lutz Ackermann*, Rubén Vicente and Nora Hofmann
*Institut für Organische und Biomolekulare Chemie,
Georg-August-Universität, Tammannstrasse 2, 37077 Göttingen, Germany, Email:
lutz.ackermannchemie.uni-goettingen.de
L. Ackermann, R. Vicente, N. Hofmann, Org. Lett., 2009, 11, 4274-4276.
DOI: 10.1021/ol901597d
Abstract
A palladium catalyst derived from an air-stable secondary phosphine oxide enabled efficient intramolecular α-arylations of amides with aryl chlorides to give various substituted oxindoles and azaoxindoles in good yield.
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ID: J54-Y2009-2820