Iron-Catalyzed Cross-Coupling of Alkyl Sulfonates with Arylzinc Reagents

Shingo Ito, Yu-ichi Fujiwara, Eiichi Nakamura and Masaharu Nakamura*

*Institute for Chemical Research, and Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Uji, Kyoto 611-0011, Japan, Email: masaharuscl.kyoto-u.ac.jp

S. Ito, Y.-i. Fujiwara, E. Nakamura, M. Nakamura, Org. Lett., 2009, 11, 4306-4309.

DOI: 10.1021/ol901610a

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Abstract

Iron-catalyzed cross-coupling of primary and secondary alkyl sulfonates with arylzinc reagents, prepared from the corresponding aryllithium or magnesium reagents with ZnI₂, proceeds smoothly in the presence of excess TMEDA and a concomitant magnesium salt.

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Iron-Catalyzed Cross-Coupling of Primary and Secondary Alkyl Halides with Aryl Grignard Reagents

M. Nakamura, K. Matsuo, S. Ito, E. Nakamura, J. Am. Chem. Soc., 2004, 126, 3686-3687.

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Key Words

Alkylation

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ID: J54-Y2009-2850