A General Procedure for the Preparation of β-Ketophosphonates
Kevin M. Maloney* and John Y. L. Chung
*Department of Process Research, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, Email: kevin_maloneymerck.com
K. M. Maloney, J. Y. L. Chung, J. Org. Chem., 2009, 74, 7574-7576.
DOI: 10.1021/jo901552k (free Supporting Information)
A mild, high-yielding and general procedure for the preparation of β-ketophosphonates by condensation of esters and phosphonates provides products in high yields within minutes at 0°C. The reaction procedure is operationally simple and amenable to large-scale preparations.
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