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Synthesis of α-Aminonitriles through Strecker Reaction of N-Tosylaldimines Using Molecular Iodine

Biswanath Das*, Penagaluri Balasubramanyam, Maddeboina Krishnaiah, Boyapati Veeranjaneyulu, Gandolla Chinna Reddy

*Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500007, India, Email:

B. Das, P. Balasubramanyam, M. Krishnaiah, B. Veerenjaneyulu, G. C. Reddy, Synthesis, 2009, 3467-3471.

DOI: 10.1055/s-0029-1216969


The Strecker reaction of N-tosylaldimines with trimethylsilyl cyanide in the presence of catalytic amount of iodine at room temperature produces the corresponding protected α-aminonitriles in high yields.

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Key Words

Strecker Synthesis, N-tosylaldimine, trimethylsilyl cyanide, protected α-aminonitriles, iodine

ID: J66-Y2009-2920