A Powerful Reagent for Synthesis of Weinreb Amides Directly from Carboxylic Acids

Teng Niu, Weiming Zhang, Danfeng Huang*, Changming Xu, Haifeng Wang and Yulai Hu*

*College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning Road (E.), Lanzhou 730070, P. R. China, Email: huylnwnu.edu.cn, huangdfnwnu.edu.cn

T. Niu, W. Zhang, D. Huang, C. Xu, H. Wang, Y. Hu, Org. Lett., 2009, 11, 4474-4477.

DOI: 10.1021/ol901886u

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Abstract

P[NCH₃(OCH₃)]₃ is a powerful reagent for conversion of aromatic and aliphatic carboxylic acids, including sterically hindered substrates, directly to Weinreb amides in excellent yields in toluene as solvent.

see article for more reactions

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One-Pot Transition-Metal-Free Synthesis of Weinreb Amides Directly from Carboxylic Acids

T. Niu, K.-H. Wang, D. Huang, C. Xu, Y, Su, Y. Hu, Y. Fu, Synthesis, 2014, 46, 320-330.

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Key Words

Weinreb Amides

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ID: J54-Y2009-2950