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Palladium-Catalyzed Direct Arylation-Based Domino Synthesis of Annulated N-Heterocycles Using Alkenyl or (Hetero)Aryl 1,2-Dihalides

Lutz Ackermann*, Andreas Althammer, Peter Mayer

*Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstr. 2, 37077 Göttingen, Germany, Email:

L. Ackermann, A. Althammer, P. Mayer, Synthesis, 2009, 3493-3503.

DOI: 10.1055/s-0029-1216977

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A palladium-catalyzed reaction sequence consisting of an intermolecular amination and an intramolecular direct arylation enabled highly regioselective syntheses of functionalized indoles or carbazoles and proved to be amenable to the use of inexpensive 1,2-dichloroarenes as electrophiles.

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Key Words

arylation, catalysis, heterocycles, carbazoles, palladium, sequential reaction

ID: J66-Y2009-2980