Iron-Catalyzed Negishi Coupling Toward an Effective Olefin Synthesis
Takuji Hatakeyama, Naohisa Nakagawa and Masaharu Nakamura*
*Department of Energy and Hydrocarbon Chemistry, Graduate
School of Engineering, Kyoto University, Uji, Kyoto 611-0011, Japan, Email:
masaharu
scl.kyoto-u.ac.jp
T. Niu, W. Zhang, D. Huang, C. Xu, H. Wang, Y. Hu, Org. Lett., 2009, 11, 4474-4477.
DOI: 10.1021/ol901555r
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Abstract
A selective iron-catalyzed cross-coupling of primary and secondary alkyl chlorides, bromides, and iodides with alkenylzinc reagents gives the corresponding olefins in good to excellent yields in a stereospecific manner. High functional group compatibility is also demonstrated by using combinations of substrates possessing rather reactive substituents.
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Key Words
ID: J54-Y2009-2990
