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C-H Bond Activation: A Versatile Protocol for the Direct Arylation and Alkenylation of Oxazoles

François Besselièvre, Sabrina Lebrequier, Florence Mahuteau-Betzer, Sandrine Piguel*

*Univ Paris-Sud 11, 91405 Orsay, France, Email:

F. Besselièvre, S. Lebrequier, F. Mahuteau-Betzer, S. Piguel, Synthesis, 2009, 3511-3512.

DOI: 10.1055/s-0029-1216987


Pd(PPh3)4 efficiently catalyses both direct arylation and alkenylation of oxazoles. The method is regio- and stereospecific with respect to bromoalkenes and tolerates a wide range of functional groups.

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Key Words

oxazoles, arylation, alkenylation, palladium, C-H activation

ID: J66-Y2009-3050