A Highly Active Catalyst for Huisgen 1,3-Dipolar Cycloadditions Based on the Tris(triazolyl)methanol-Cu(I) Structure
Salih Özçubukçu, Erhan Ozkal, Ciril Jimeno and Miquel A. Pericàs*
*Institute of Chemical Research of Catalonia (ICIQ), Av.
Països Catalans, 16. 43007 Tarragona, Spain, Email: mapericas
iciq.es
S. Özçubukçu, E. Ozkal, C. Jimeno, M. A. Pericàs, Org. Lett., 2009, 11, 4680-4683.
DOI: 10.1021/ol9018776
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Abstract
Tris(1-benzyl-1H-1,2,3-triazol-4-yl)methanol forms a stable complex with CuCl, which catalyzes the 1,3-dipolar cycloaddition of alkynes with azides on water or under neat conditions. Low catalyst loadings, short reaction times at room temperature, and compatibility with free amino groups make this complex an outstanding catalyst for CuAAC.
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Key Words
1,2,3-Triazoles, Click Chemistry
ID: J54-Y2009-3060
