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Phenyl 4,5-Dichloro-6-Oxopyridazine-1(6H)-Carboxylate as Carbonyl Source: Facile and Selective Synthesis of Carbamates and Ureas under Mild Conditions

Hyung-Geun Lee, Min-Jung Kim, Song-Eun Park, Jeum-Jong Kim, Bo Ram Kim, Sang-Gyeong Lee, Yong-Jin Yoon*

*Department of Chemistry, Gyeongsang National University, Jinju Gyeognam 660-701, Korea, Email:

H.-G. Lee, M.-J. Kim, S.-E. Park, J.-J. Kim, S.-G. Lee, Y.-J. Yoon, Synlett, 2009, 2809-2814.

DOI: 10.1055/s-0029-1217997 (free Supporting Information)

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Selective and convenient syntheses of carbamates, symmetric ureas, and unsymmetrical ureas have been accomplished by the reaction of amines with phenyl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylate as a carbonyl source under mild conditions.

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2-Acylpyridazin-3-ones: Novel Mild and Chemoselective Acylating Agents for Amines

Y.-J. Kang, H.-A Chung, J.-J. Kim, Y.-J. Yoon, Synthesis, 2002, 733-738.

Key Words

carbamates, ureas, carbonyl source, pyridazinones

ID: J60-Y2009-3070