Facile Synthesis of 1,2,4-Triazoles via a Copper-Catalyzed Tandem Addition-Oxidative Cyclization
Satoshi Ueda and Hideko Nagasawa*
*Laboratory of Medicinal and Pharmaceutical Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan, Email: hnagasawagifu-pu.ac.jp
S. Ueda, H. Nagasawa, J. Am. Chem. Soc., 2009, 131, 15080-15081.
DOI: 10.1021/ja905056z (free Supporting Information)
A copper-catalyzed reaction under an atmosphere of air provides 1,2,4-triazole derivatives by sequential N-C and N-N bond-forming oxidative coupling reactions. Starting materials and the copper catalyst are readily available and inexpensive. A wide range of functional groups are tolerated.
see article for more examples