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Facile Synthesis of 1,2,4-Triazoles via a Copper-Catalyzed Tandem Addition-Oxidative Cyclization

Satoshi Ueda and Hideko Nagasawa*

*Laboratory of Medicinal and Pharmaceutical Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan, Email:

S. Ueda, H. Nagasawa, J. Am. Chem. Soc., 2009, 131, 15080-15081.

DOI: 10.1021/ja905056z


A copper-catalyzed reaction under an atmosphere of air provides 1,2,4-triazole derivatives by sequential N-C and N-N bond-forming oxidative coupling reactions. Starting materials and the copper catalyst are readily available and inexpensive. A wide range of functional groups are tolerated.

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Key Words

1,2,4-triazolo[1,5-a]pyridines, 1,2,4-triazoles, oxygen

ID: J48-Y2009-3080