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A Simple One-Pot Synthesis of 2-Aryl-5-alkyl-Substituted Oxazoles by Cs2CO3-Mediated Reactions of Aromatic Primary Amides with 2,3-Dibromopropene

Nasima Yasmin, Jayanta K. Ray*

*Department of Chemistry, Indian Institute of Technology, Kharagpur-721302, India, Email: jkraychem.iitkgp.ernet.in

N. Yasmin, J. K. Ray, Synlett, 2009, 2825-2827.

DOI: 10.1055/s-0029-1217995 (free Supporting Information)


Abstract

A simple and efficient Cs2CO3-mediated reaction of aromatic and unsaturated primary amides with 2,3-dibromopropene allows the synthesis of 2-aryl-5-alkyl-substituted oxazoles in a single step in good yields.

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proposed reaction pathway



Key Words

substituted oxazoles, aromatic primary amides, 2,3-dibromopropene, cesium carbonate, dimethylsulfoxide


ID: J60-Y2009-3110