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Direct Cobalt-Catalyzed Cross-Coupling Between Aryl and Alkyl Halides

Waldemar Maximilian Czaplik, Matthias Mayer, Axel Jacobi von Wangelin*

*Department of Chemistry, University of Cologne, Greinstr. 4, 50939 Cologne, Germany, Email:

W. M. Czaplik, M. Mayer, A. J. von Wangelin, Synlett, 2009, 2931-2934.

DOI: 10.1055/s-0029-1218012


An operationally simple cross-coupling reaction between aryl halides and alkyl halides with high selectivity utilizes CoCl2/Me4-DACH as a catalyst system. The underlying domino process exhibits high sustainability as it obviates the need for the pre-formation and handling of stoichiometric amounts of hazardous Grignard compounds.

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Key Words

cobalt, cross-coupling, aryl halides, domino reactions, magnesium

ID: J60-Y2009-3140