General Reaction Conditions for the Palladium-Catalyzed Vinylation of Aryl Chlorides with Potassium Alkenyltrifluoroborates
Emilio Alacid and Carmen Nájera*
*Departamento de Qíumica Orgánica, Facultad de Ciencias, and Instituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, 03080-Alicante, Spain, Email: cnajeraua.es
E. Alacid, C. Nájera, J. Org. Chem., 2009, 74, 8191-8195.
DOI: 10.1021/jo901681s
Abstract
Activated and deactivated aryl and heteroaryl chlorides are efficiently cross-coupled with potassium alkenyltrifluoroborates using 4-hydroxyacetophenone oxime derived palladacycle as precatalyst, Binap as ligand, and Cs2CO3 as base in DMF at 120 °C. The corresponding cross-coupled compounds are obtained in good yields and with high regio- and diastereoselectivity.
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E. Alacid, C. Nájera, J. Org. Chem., 2009, 74, 2321-2327.
Key Words
ID: J42-Y2009-3170