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Catalytic Direct Arylations in Polyethylene Glycol (PEG): Recyclable Palladium(0) Catalyst for C-H Bond Cleavages in the Presence of Air

Lutz Ackermann* and Rubén Vicente

*Institut fuer Organische und Biomolekulare Chemie, Georg-August-Universitaet, Tammannstrasse 2, 37077 Goettingen, Germany, Email:

L. Ackermann, R. Vicente, Org. Lett., 2009, 11, 4922-4925.

DOI: 10.1021/ol9020354

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The use of nontoxic polyethylene glycol (PEG) as solvent and MesCO2H as cocatalyst enabled user-friendly palladium(0)-catalyzed C-H bond functionalizations under air in the absence of phosphine ligands. Direct arylations of 1,2,3-triazoles gave substituted triazoles in good yields. Recycling of the catalytic system led to a slight decrease of activity.

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Key Words

1,2,3-Triazoles, Heterobiaryls

ID: J54-Y2009-3180