Simple Reaction Conditions for the Formation of Ketonitrones from Ketones and Hydroxylamines
Jennifer Y. Pfeiffer and André M. Beauchemin
*Centre for Catalysis Research and Innovation, Department of
Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada, K1N
6N5, Email: andre.beauchemin
uottawa.ca
J. Y. Pfeiffer A. M. Beauchemin, J. Org. Chem., 2009, 74, 8381-8383.
DOI: 10.1021/jo901653d
Abstract
Simple thermal conditions, previously found to minimize hydroxylamine decomposition (t-BuOH, 110 °C), allow the condensation of ketones and hydroxylamines to form exocyclic, acyclic, and α,β-unsaturated ketonitrones with benzylic, linear, and branched nitrogen substituents in modest to excellent isolated.
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Key Words
ID: J42-Y2009-3220
