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A simple and highly efficient synthesis of β-amino-α,β-unsaturated ester via sonochemical Blaise reaction

Adam Shih-Yuan Lee* and Rae-Yi Cheng

*Department of Chemistry, Tamkang University, Taipei, Taiwan 251, Email:

A. S.-Y. Lee, R.-Y. Cheng, Tetrahedron Lett., 1997, 38, 443-446.

DOI: 10.1016/S0040-4039(96)02321-0


β-Amino-α,β-unsaturated esters are produced by a sonochemical Blaise reaction of nitriles, zinc powder, zinc oxide and ethyl bromoacetate in THF in a commercial ultrasonic cleaning bath.

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Key Words

Blaise Reaction, β-enamino esters, sonochemistry

ID: J72-Y1997-770