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Zinc Chloride-Promoted Aryl Bromide-Alkyne Cross-Coupling Reactions at Room Temperature

Aaron D. Finke, Eric C. Elleby, Michael J. Boyd, Haim Weissman and Jeffrey S. Moore*

*Department of Chemistry, University of Illinois Urbana−Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, Email:

A. D. Finke, E. C. Elleby, M. J. Boyd, H. Weissman, J. S. Moore, J. Org. Chem., 2009, 74, 8897-8900.

DOI: 10.1021/jo902015w (free Supporting Information)


Substoichiometric amounts of ZnCl2 promote a room temperature, Pd/P(t-Bu)3-catalyzed cross-coupling of aryl bromides with alkynes. A Pd(I) dimer is a particularly active precatalyst for this reaction. The reaction is general for a broad range of aryl bromides.

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ID: J42-Y2009-3380