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One-Pot Synthesis of Sulfonamides from Primary and Secondary Amine Derived Sulfonate Salts Using Cyanuric Chloride

Mohammad Navid Soltani Rad*, Ali Khalafi-Nezhad, Zeinab Asrari, Somayeh Behrouz, Zohreh Amini, Marzieh Behrouz

*Department of Chemistry, Faculty of Basic Sciences, Shiraz University of Technology, Shiraz 71555-313, Iran, Email:

M. N. S. Rad, A. Khalafi-Nezhad, Z. Asrari, S. Behrouz, Z. Amini, M. Behrouz, Synthesis, 2009, 3983-3988.

DOI: 10.1055/s-0029-1217020


A mild and efficient reaction of amine derived sulfonate salts in the presence of cyanuric chloride, triethylamine as base, and anhydrous acetonitrile as solvent at room temperature gives the corresponding sulfonamides in good to excellent yields.

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Key Words

one-pot reaction, sulfonamides, toluenesulfonamides, amine-sulfonate salt, cyanuric chloride, triethylamine

ID: J66-Y2009-3450