One-Pot Synthesis of Sulfonamides from Primary and Secondary Amine Derived Sulfonate Salts Using Cyanuric Chloride
Mohammad Navid Soltani Rad*, Ali Khalafi-Nezhad, Zeinab Asrari, Somayeh Behrouz, Zohreh Amini, Marzieh Behrouz
*Department of Chemistry, Faculty of Basic Sciences, Shiraz
University of Technology, Shiraz 71555-313, Iran, Email: soltani
sutech.ac.ir
M. N. S. Rad, A. Khalafi-Nezhad, Z. Asrari, S. Behrouz, Z. Amini, M. Behrouz, Synthesis, 2009, 3983-3988.
Abstract
A mild and efficient reaction of amine derived sulfonate salts in the presence of cyanuric chloride, triethylamine as base, and anhydrous acetonitrile as solvent at room temperature gives the corresponding sulfonamides in good to excellent yields.
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Key Words
one-pot reaction, sulfonamides, toluenesulfonamides, amine-sulfonate salt, cyanuric chloride, triethylamine
ID: J66-Y2009-3450
