Efficient Synthesis of 3-Arylphthalides using Palladium-Catalyzed Arylation of Aldehydes with Organoboronic Acids
Masami Kuriyama*, Natsuki Ishiyama, Rumiko Shimazawa, Ryuichi Shirai and Osamu Onomura*
*Graduate School of Biomedical Sciences, Nagasaki University,
1-14 Bunkyo-machi, Nagasaki 852-8521, Japan, Email: mkuriyam
nagasaki-u.ac.jp,
onomuranagasaki-u.ac.jp
M. Kuriyama, N. Ishiyama, R. Shimazawa, R. Shirai, O. Onomura, J. Org. Chem., 2009, 74, 9210-9213.
DOI: 10.1021/jo901964k
see article for more reactions
Abstract
A palladium-catalyzed arylation of aldehydes with organoboronic acids gave 3-arylphthalides in good to excellent yields with high substrate tolerance in the presence of a thioether-imidazolinium carbene ligand.
see article for more examples
Key Words
ID: J42-Y2009-3500
