Palladium-Catalyzed Cross-Coupling Reaction of Secondary Benzylic Bromides with Grignard Reagents
Ana López-Pérez, Javier Adrio* and Juan C. Carretero*
*Departamento de Química Orgánica, Facultad de Ciencias,
Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain, Email:
javier.adrio
uam.es, juancarlos.carreterouam.es
A. López-Pérez, J. Adrio, J. C. Carretero, Org. Lett., 2009, 11, 5514-5517.
DOI: 10.1021/ol902335c
Abstract
The use of the Xantphos ligand in a mild palladium-catalyzed Kumada-Corriu reaction of secondary benzylic bromides with aryl and alkenyl Grignard reagents minimizes the undesired β-elimination pathway. The corresponding cross-coupling products can be isolated in good yields with inversion of the configuration.
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Key Words
Kumada Coupling, Benzylation, Diarylmethanes, Alkenes
ID: J54-Y2009-3530
