Organic Chemistry Portal



A One-Pot, Four-Component Synthesis of N-Substituted 2,4-Diarylimidazoles

Mehdi Adib*, Samira Ansari, Shahzad Feizi, Jafar Asgarian Damavandi, Peiman Mirzaei

*School of Chemistry, University College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran, Email:

M. Adib, S. Ansari, S. Feizi, J. A. Damavandi, P. Mirzaei, Synlett, 2009, 3263-3266.

DOI: 10.1055/s-0029-1218381


A one-pot, four-component synthesis of 1,2,4-trisubstituted 1H-imidazoles was achieved in very good yields by heating a mixture of a 2-bromoacetophenone, an aldehyde, a primary amine, and ammonium acetate under solvent-free conditions.

see article for more examples

proposed mechanism

Key Words

1,2,4-trisubstituted 1H-imidazoles, imidazoles, aldehydes, primary amines, four-component reactions, multicomponent reactions, green chemistry, cyclizations, heterocycles

ID: J60-Y2009-3560