Microwave Irradiation as an Effective Means of Synthesizing Unsubstituted N-Linked 1,2,3-Triazoles from Vinyl Acetate and Azides
Signe Grann Hansen, Henrik Helligsų Jensen*
*Department of Chemistry, Aarhus University, Langelandsgade
140, 8000 Aarhus C, Denmark, Email: hhj
chem.au.dk
S. G. Hansen, H. H. Jensen, Synlett, 2009, 3275-3278.
DOI: 10.1055/s-0029-1218366
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Abstract
1-Monosubstituted 1,2,3-triazoles have been prepared by a reaction of azides with vinyl acetate under microwave irradiation. Additionally, a microwave-assisted, two-step, one-pot procedure from halides involving azide substitution using TBAN3 in diethyl ether, followed by reaction with vinyl acetate, has effectively been employed.
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Key Words
1,2,3-triazoles, vinyl acetate, microwave synthesis, one-pot reaction, Huisgen 1,3-dipolar cycloaddition, Click Chemistry
ID: J60-Y2009-3590
